Constructed in 1516, this structure is reputed to be Cuba's oldest house one of the oldest in the Americas, although many historians now doubt that claim. Noticeable for its black-slatted balconies, it is one of Santiago's top attractions. Diego Velázquez, the Spanish conquistador who founded the city and was the island's first governor, lived upstairs. At the moment this old house works as Cuban Historical Colonial Environment's Museum, its rooms overflow with period furniture and carved woodwork and encircle­ two lovely courtyards. Inside you'll find period beds, desks, chests, and other furniture. On the first floor is a gold foundry. Memorable are the star-shape Moorish carvings on the wooden windows and balconies, and the original interior patio with its well and rain-collecting tinajón vessel. An adjacent house is filled with antiques intended to convey the French and English decorative and architectural influences—such as the radial stained glass above the courtyard doors—in the late 19th-century.

The Spanish fortress known as El Morro, south of Santiago, was constructed between 1638 and 1700 and was designed by Giovanni Antonelli, the Italian architect and engineer responsible for fortresses bearing the same name in both Havana and San Juan, Puerto Rico. El Morro was built to ward off pirates (and rebuilt after a 1662 attack by the English pirate Henry Morgan). Today, its solid walls house the Museum of Piracy, its rooms also reflects the main events connected with the naval battle of Santiago de Cuba, episode of the Spanish-Cuban-American in 1898 and photographs related to the events of Maine , the Spanish and U.S. military leaders, Admiral Pascual Cervera and Vice Admiral Sampson and planes and coastal defenses and batteries of El Morro. There are wonderful views from interior rooms, which have wooden floors and stone walls, as well as from various terraces.

Visit San Juan Historic Park, a place where it was developed an important battle of the North American-Cuban-Hispanic War, bringing the end to an era. At the helm of a brigade at this battle was a future president of the United States, Theodore Roosevelt. The Peace Tree (Árbol de la Paz) is the tree in which it was signed the surrender of Santiago de Cuba. In the San Juan Hill you can admire various monuments in memory of the numbered casualties in both sides in the battle developed in the surroundings of Santiago on the first of July 1898. You can witness sculptures to the Victorious Mambí, to the Unknown North American Soldier and to the Spaniard Soldier surrounded by a series of cannons and artillery objects decorating the place. This is the only place in Cuba with a monument to the American soldier. Furthermore, quite close to the hill, a ceiba tree named the Peace Tree (Árbol de la Paz) witnessed the surrender of the city, although nowadays just remains the trunk of this historic tree which fell few months after the centenary of the battle.    

One of the most beautiful Biosphere Reserves in Cuba. The big areas offer different geographical contrasts such as marine terraces and mountainous elevations with a exuberant vegetation that endow this site like an unforgettable place to be in contact with an almost virgin nature. This park covers an extensive area of forest, offering visitors numerous attractions such as the Valley of Prehistory, the Museum of Land Transport, the Great Lagoon of Baconao, Daiquirí beach and the Great Stone, a stunning viewing point in the ruins of a French coffee plantation.